General Information

  • ID:  hor004109
  • Uniprot ID:  P82617
  • Protein name:  Pyrokinin-5
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  Mainly in abdominal perisympathetic organs and to a lesser extent in retrocerebral complex.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GGGGSGETSGMWFGPRL
  • Length:  17(1-17)
  • Propeptide:  GGGGSGETSGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T17 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P82617-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P82617-F1.pdbhor004109_AF2.pdbhor004109_ESM.pdb

Physical Information

Mass: 193836 Formula: C71H105N21O23S
Absent amino acids: ACDHIKNQVY Common amino acids: G
pI: 6.41 Basic residues: 1
Polar residues: 10 Hydrophobic residues: 3
Hydrophobicity: -41.76 Boman Index: -1194
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 22.94
Instability Index: 2231.76 Extinction Coefficient cystines: 5500
Absorbance 280nm: 343.75

Literature

  • PubMed ID:  10196736
  • Title:  Differential Distribution of Pyrokinin-Isoforms in Cerebral and Abdominal Neurohemal Organs of the American Cockroach.
  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.